How is eGFR Linked to Kidney Health?

How is eGFR Linked to Kidney Health?

Kidneys are named "the silent organ" for a reason. Typically, there are no signs of early kidney function decline. It is common for people to accidentally find out they have kidney function decline when they go for a body check. A regular kidney function test is undoubtedly crucial in kidney protection. The earlier we catch the problems, the sooner we can manage them and delay the progression.


Kidney function test usually consists of basic urine and blood test. They are used to assess how well the kidneys can filter blood metabolites. Based on different testing items, various renal function indicators help reflect the kidneys' health status, including estimated glomerular filtration rate, serum creatinine, blood urea nitrogen, etc. We have another post, "Know Your Kidney Healthy By Understanding Your Lab Tests," which covers more about the differences among those indicators. And we will focus on the estimated glomerular filtration rate eGFR and how it can reflect kidney health in depth.


What is Glomerular Filtration Rate eGFR?

eGFR measures the total amount of blood the kidney can purify in one minute. A higher number refers to better kidney function. In contrast, a lower number of eGFR means weaker kidney function and more metabolic waste remains in the blood.


The eGFR number is calculated by formula. Cockcroft-Gault formula and MDRD formula are the formulas that are commonly used.


Cockcroft-Gault Formula

Male: (140 – age) x weight (kg) / (72 x serum creatinine)

Female: above formula x 0.85


Abbreviated MDRD Formula

Male: 186 x serum creatinine-1.154 x age-0.203

Female: above formula x 0.742


Each formula has its advantages and limitation. For example, most of these formulas may not reflect Asian kidney function accurately as the database was not based on Asian race. Therefore, in recent years, several Asian countries have begun to develop their eGFR calculation to suit their nationals better.



How to interpret eGFR?

Most healthy young adults have an eGFR of 110 – 120 ml/min/1.73m2. However, eGFR will gradually decline with age, with an average drop of 1 ml/min/1.73m2 per year after age 40.


If the eGFR decreases with age, how do we differentiate it from chronic kidney problems?


Chronic kidney problems are when there is kidney damage for more than 3 months, leading to irreversible structural change or function loss. If one meets any of the following criteria, they have chronic kidney problems:


1. The eGFR is greater than 60 ml/min/1.73m2, and there is evidence of kidney damage, such as excessive protein or blood present in the urine or abnormalities found in other kidney tests for more than 3 months.


2. Regardless of any renal damage found, the eGFR is less than 60 ml/min/1.73m2 for more than 3 months.


Chronic kidney problems can be divided into 5 stages.

1. Stage 1: The eGFR level is 90 ml/min/1.73m2, and there are signs of kidney injury.

2. Stage 2: The eGFR level is 60 -89 ml/min/1.73m2 with signs of kidney injury.

3. Stage 3: The eGFR level is 30-59 ml/min/1.73m2, with a rise in kidney damage.

4. Stage 4: The eGFR level is 15-29 ml/min/1.73m2. The kidney function has significantly reduced.

5. Stage 5: The eGFR level is below 15 ml/min/1.73m2.


What to do with a low eGFR?

If kidney injury is discovered in the early stage, follow the instruction advised by healthcare providers, for example, lifestyle changes, to address the leading cause of kidney damage. It will be necessary to start monitoring kidney function regularly. The aim is to maintain normal kidney function. For moderate to severe chronic kidney problems, cooperate with the doctor's treatment. Restriction on diet or fluid may be needed in these stages. For the end stage, healthcare providers will start preparing patients for dialysis or transplant.





  • * All research and clinical data should be used as reference purposes only, results may vary.
Chronic kidney problems are conditions that require individuals to be mindful of their dietary choices, particularly when it comes to sodium intake. Sodium is a vital mineral that plays various roles in the body, but excessive consumption can pose risks, especially for those with low kidney function.   Recommended Sodium Intake for Chronic Kidney Problems: According to a 2018 study and the National Kidney Foundation, the current recommended
Having a single kidney is not as uncommon as one might think. Whether one was born with only one kidney or had one surgically removed, it’s important to understand how this condition can affect one’s life and what precautions should be taken to maintain kidney health.   Most people with a single kidney can lead  normal and healthy lives. In fact, our kidneys are highly efficient organs, and having just one functioning kidney is usually sufficient to p
Hit Questions
How long does it take to see results? Should I stop taking it after a while? Are there any side effects? These are some of the most common questions we get, and let’s find out the answer together.   How long does it take to see results? Results often vary among different users, as no two individuals have the same condition, diet, and lifestyles, which could all play parts in the effects of DTS. Kidney damage is known to be irreversible
DTS is scientifically proven to be beneficial to kidney function and has a positive effect on supporting the eGFR level. It is suitable for people to use as kidney support. Some may wonder, how about individuals without any kidney issues? Is DTS good for them too?   Absolutely yes! As “prevention is better than cure” is one of the basic modern healthcare strategies, the best time to take DTS is right before any kidney and liver problems show up. The herbal
Using creatinine as an indication of kidney function level is common, but just this number alone is not the optimal way to monitor kidney health nor to detect early kidney problems. According to professional recommendations, using an eGFR level is a more accurate indication of kidney health.   Creatinine is a by-product generated from protein metabolism. Therefore, muscle mass and diet can affect creatinine generation. For example, a muscular person or a person who cr
If the urine shows pink, red, or even brownish-red color instead of pale yellow, the first thing is to recall is the discolored urine caused by red pigments from medications or food like beetroots and red dragon fruit. If not, maybe it’s time to think about the possibility of blood present in the urine.   Blood in the urine is just a symptom, and sometimes it is not possible to see blood in the urine with naked eyes. A lab test is required to check for red blood
Have Questions?

Submit your question to us for profeessional answers!

Want to know more about DTS?
Send us your questions right away!

Contact us