Q:

How is eGFR Linked to Kidney Health?

How is eGFR Linked to Kidney Health?
A:

Kidneys are named "the silent organ" for a reason. Typically, there are no signs of early kidney function decline. It is common for people to accidentally find out they have kidney function decline when they go for a body check. A regular kidney function test is undoubtedly crucial in kidney protection. The earlier we catch the problems, the sooner we can manage them and delay the progression.

 

Kidney function test usually consists of basic urine and blood test. They are used to assess how well the kidneys can filter blood metabolites. Based on different testing items, various renal function indicators help reflect the kidneys' health status, including estimated glomerular filtration rate, serum creatinine, blood urea nitrogen, etc. We have another post, "Know Your Kidney Healthy By Understanding Your Lab Tests," which covers more about the differences among those indicators. And we will focus on the estimated glomerular filtration rate eGFR and how it can reflect kidney health in depth.

 

What is Glomerular Filtration Rate eGFR?

eGFR measures the total amount of blood the kidney can purify in one minute. A higher number refers to better kidney function. In contrast, a lower number of eGFR means weaker kidney function and more metabolic waste remains in the blood.

 

The eGFR number is calculated by formula. Cockcroft-Gault formula and MDRD formula are the formulas that are commonly used.

 

Cockcroft-Gault Formula

Male: (140 – age) x weight (kg) / (72 x serum creatinine)

Female: above formula x 0.85

 

Abbreviated MDRD Formula

Male: 186 x serum creatinine-1.154 x age-0.203

Female: above formula x 0.742

 

Each formula has its advantages and limitation. For example, most of these formulas may not reflect Asian kidney function accurately as the database was not based on Asian race. Therefore, in recent years, several Asian countries have begun to develop their eGFR calculation to suit their nationals better.

 

 

How to interpret eGFR?

Most healthy young adults have an eGFR of 110 – 120 ml/min/1.73m2. However, eGFR will gradually decline with age, with an average drop of 1 ml/min/1.73m2 per year after age 40.

 

If the eGFR decreases with age, how do we differentiate it from chronic kidney problems?

 

Chronic kidney problems are when there is kidney damage for more than 3 months, leading to irreversible structural change or function loss. If one meets any of the following criteria, they have chronic kidney problems:

 

1. The eGFR is greater than 60 ml/min/1.73m2, and there is evidence of kidney damage, such as excessive protein or blood present in the urine or abnormalities found in other kidney tests for more than 3 months.

 

2. Regardless of any renal damage found, the eGFR is less than 60 ml/min/1.73m2 for more than 3 months.

 

Chronic kidney problems can be divided into 5 stages.

1. Stage 1: The eGFR level is 90 ml/min/1.73m2, and there are signs of kidney injury.

2. Stage 2: The eGFR level is 60 -89 ml/min/1.73m2 with signs of kidney injury.

3. Stage 3: The eGFR level is 30-59 ml/min/1.73m2, with a rise in kidney damage.

4. Stage 4: The eGFR level is 15-29 ml/min/1.73m2. The kidney function has significantly reduced.

5. Stage 5: The eGFR level is below 15 ml/min/1.73m2.

 

What to do with a low eGFR?

If kidney injury is discovered in the early stage, follow the instruction advised by healthcare providers, for example, lifestyle changes, to address the leading cause of kidney damage. It will be necessary to start monitoring kidney function regularly. The aim is to maintain normal kidney function. For moderate to severe chronic kidney problems, cooperate with the doctor's treatment. Restriction on diet or fluid may be needed in these stages. For the end stage, healthcare providers will start preparing patients for dialysis or transplant.

 

 

 

 

Disclaimer:
  • * All research and clinical data should be used as reference purposes only, results may vary.
RELATED QUESTIONS
A:
"Can doctors know how well my kidney is functioning by simply looking at my creatinine level in blood?" That's properly a common question to ask. In short, the answer is no. Today, we will go through what creatinine is and how it is linked with kidney function.   Creatinine is a waste product produced when creatine, a molecule that provides energy to the muscles, is broken down. Creatinine is then eliminated from the body through the kidneys. When the ki
A:
Swelling is one of the common signs for people living with kidney problems. It often indicates the kidneys do not remove excess fluid. Swelling can happen in ankles, feet, or any body part. It is rather uncomfortable because it can affect walking or cause shortness of breath.   There is an easy test to get an idea if one has swelled. Press on a bony area on the lower legs for around 5 seconds. Observe any pit formed, and if there is a dimple, note the depth of the pit
Hit Questions
A:
How long does it take to see results? Should I stop taking it after a while? Are there any side effects? These are some of the most common questions we get, and let’s find out the answer together.   How long does it take to see results? Results often vary among different users, as no two individuals have the same condition, diet, and lifestyles, which could all play parts in the effects of DTS. Kidney damage is known to be irreversible
A:
DTS is scientifically proven to be beneficial to kidney function and has a positive effect on supporting the eGFR level. It is suitable for people to use as kidney support. Some may wonder, how about individuals without any kidney issues? Is DTS good for them too?   Absolutely yes! As “prevention is better than cure” is one of the basic modern healthcare strategies, the best time to take DTS is right before any kidney and liver problems show up. The herbal
A:
Using creatinine as an indication of kidney function level is common, but just this number alone is not the optimal way to monitor kidney health nor to detect early kidney problems. According to professional recommendations, using an eGFR level is a more accurate indication of kidney health.   Creatinine is a by-product generated from protein metabolism. Therefore, muscle mass and diet can affect creatinine generation. For example, a muscular person or a person who cr
A:
A study conducted in 2016 has shown that extracts from different parts of Eucommia, such as bark, stem, and seeds, contain health-promoting properties. Here are some examples:   1. Eucommia bark extract demonstrates an antihypertensive effect, confirmed by many human and animal models. 2. Under vivo and vitro studies, Eucommia has established strong antioxidant properties. 3. Eucommia leaf extract shows properties that promote the
Have Questions?

Submit your question to us for profeessional answers!

Want to know more about DTS?
Send us your questions right away!

Contact us